This revised second edition comprehensively addresses the pharmacologic principles guiding personalized patient therapy and modern drug development, emphasizing the foundational concepts essential for clinical pharmaceutical use and advancement. Authors from academia, the pharmaceutical sector, and governmental bodies cover the full spectrum of topics, including pharmacokinetic principles tested in the American Board of Clinical Pharmacology's certifying examination. This unique reference, endorsed by the Board as a study aid, incorporates modules on drug discovery and development to aid both students and practicing pharmacologists.
Key Features:
- Comprehensive coverage spanning drug discovery and development to the customization and assessment of drug therapy quality.
- Cohesive presentation resulting from author involvement in a popular ongoing NIH course.
- Instructional integration of pharmacokinetic theory and practical applications, supplemented with sample problems for self-study.
- Diverse perspectives from authors representing Federal agencies, academia, and the pharmaceutical industry.
- Expanded discussion on pharmacogenetics and drug transporters, including their impact on interactions.
- Addition of new material discussing enzyme induction mechanisms within chapters on drug metabolism and interactions.
- Introduction of a new chapter focusing on oncologic agents in drug discovery.
- Incorporation of therapeutic antibodies within the chapter on biotechnology products.
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