Goodman & Gilman's: - The Pharmacological Basis of Therapeutics 12th Edition

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Goodman & Gilman's: - The Pharmacological Basis of Therapeutics 12th Edition

Goodman & Gilman's

The Pharmacological Basis of Therapeutics

12th Edition

Goodman & Gilman’s: The Pharmacological Basis of Therapeutics indeed holds a distinguished place in the field of pharmacology, serving as a comprehensive resource for understanding the actions, uses, and effects of therapeutic agents. Its rigorous approach, balancing fundamental science with clinical application, has made it invaluable to practitioners and students alike.

 

The Thwelveth Edition, with its wealth of color illustrations and updated content, further solidifies its reputation as a leading authority in pharmacology. The addition of new chapters on topics such as Treatment of Pulmonary Arterial Hypertension and Immunoglobulins and Vaccines reflects the evolving landscape of medical science.

 

Expanded coverage of cardiovascular disease and increased emphasis on cellular signaling pathways provide readers with a thorough understanding of drug mechanisms and their clinical implications. The inclusion of summary tables, chapter outlines, and abbreviation boxes enhances the accessibility and usability of the text, making it a practical tool for prescribing decisions in real-world practice.

 

In essence, Goodman & Gilman’s remains not just a textbook, but a vital resource and guide for clinicians navigating the complexities of pharmacotherapy in the treatment and management of disease.


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Contents



Section I: General Principles

Chapter 1: Drug Discovery: From Medicinal Plants to Computer-Aided Drug Design

Chapter 2: Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination

Chapter 3: Pharmacodynamics: Molecular Mechanisms of Drug Action

Chapter 4: Membrane Transporters and Drug Response

Chapter 5: Drug Metabolism

Chapter 6: The Gastrointestinal Microbiome and Drug Response

Chapter 7: Pharmacogenetics and Pharmacogenomics

Chapter 8: Postmarketing Drug Safety

Chapter 9: Principles of Clinical Toxicology


Section II: Neuropharmacology

Chapter 10: Neurotransmission: The Autonomic and Somatic Motor Nervous Systems

Chapter 11: Muscarinic Receptor Agonists and Antagonists

Chapter 12: Anticholinesterase Inhibitors and Reactivators

Chapter 13: Neuromuscular Junction and Autonomic Ganglia; Nicotine, Muscle Relaxants, and Spasmolytics

Chapter 14: Adrenergic Agonists and Antagonists

Chapter 15: 5-Hydroxytryptamine (Serotonin) and Dopamine

Chapter 16: Neurotransmission in the Central Nervous System

Chapter 17: The Blood-Brain Barrier and Its Influence on Drug Transport to the Brain

Chapter 18: Drug Therapy of Depression and Anxiety Disorders

Chapter 19: Pharmacotherapy of Psychosis and Mania

Chapter 20: Pharmacotherapy of the Epilepsies

Chapter 21: Treatment of Central Nervous System Degenerative Disorders

Chapter 22: Hypnotics and Sedatives

Chapter 23: Opioid Analgesics

Chapter 24: General Anesthetics and Therapeutic Gases

Chapter 25: Local Anesthetics

Chapter 26: Cannabinoids

Chapter 27: Ethanol

Chapter 28: Drug Use Disorders and Addiction


Section III: Modulation of Pulmonary, Renal, and Cardiovascular

Chapter 29: Drugs Affecting Renal Excretory Function

Chapter 30: Renin and Angiotensin

Chapter 31: Treatment of Ischemic Heart Disease

Chapter 32: Treatment of Hypertension

Chapter 33: Therapy of Heart Failure

Chapter 34: Antiarrhythmic Drugs

Chapter 35: Treatment of Pulmonary Arterial Hypertension

Chapter 36: Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs

Chapter 37: Drug Therapy for Dyslipidemias


Section IV: Inflammation, Immunomodulation, and Hematopoiesis

Chapter 38: Introduction to Immunity and Inflammation

Chapter 39: Immunosuppressants, Immunomodulation, and Tolerance

Chapter 40: Immune Globulins and Vaccines

Chapter 41: Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor

Chapter 42: Pharmacotherapy of Inflammation, Fever, Pain, and Gout

Chapter 43: Histamine, Bradykinin, and Their Antagonists

Chapter 44: Pulmonary Pharmacology

Chapter 45: Hematopoietic Agents: Growth Factors, Minerals, and Vitamins


Section V: Endocrine Pharmacology

Chapter 46: Introduction to Endocrinology: The Hypothalamic-Pituitary Axis

Chapter 47: Thyroid and Antithyroid Drugs

Chapter 48: Estrogens, Progestins, and the Female Reproductive Tract

Chapter 49: Androgens and the Male Reproductive Tract

Chapter 50: Adrenocorticotropic Hormone, Adrenal Steroids, and the Adrenal Cortex

Chapter 51: Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia

Chapter 52: Agents Affecting Mineral Ion Homeostasis and Bone Turnover


Section VI: Gastrointestinal Pharmacology

Chapter 53: Pharmacotherapy for Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease

Chapter 54: Gastrointestinal Motility and Water Flux, Emesis, and Biliary and Pancreatic Disease

Chapter 55: Pharmacotherapy of Inflammatory Bowel Disease


Section VII: Chemotherapy of Infectious Diseases

Chapter 56: General Principles of Antimicrobial Therapy

Chapter 57: DNA Disruptors: Sulfonamides, Quinolones, and Nitroimidazoles

Chapter 58: Cell Envelope Disruptors: β-Lactam, Glycopeptide, and Lipopeptide Antibacterials

Chapter 59: Miscellaneous Antibacterials: Aminoglycosides, Polymyxins, Urinary Antiseptics, Bacteriophages

Chapter 60: Protein Synthesis Inhibitors

Chapter 61: Antifungal Agents

Chapter 62: Antiviral Agents (Nonretroviral)

Chapter 63: Treatment of Viral Hepatitis (HBV/HCV)

Chapter 64: Antiretroviral Agents and Treatment of HIV Infection

Chapter 65: Chemotherapy of Tuberculosis and Nontuberculous Mycobacteria, Including Leprosy

Chapter 66: Chemotherapy of Malaria

Chapter 67: Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections

Chapter 68: Chemotherapy of Helminth Infections


Section VIII: Pharmacotherapy of Neoplastic Disease

Chapter 69: General Principles in the Pharmacotherapy of Cancer

Chapter 70: Cytotoxics and Antimetabolites

Chapter 71: Protein Kinase Inhibitors and Pathway-Targeted Small Molecules

Chapter 72: Antibodies, CAR T Cells, and Proteins to Treat Cancer

Chapter 73: Hormones, Hormone Receptor Antagonists, and Related Agents in the Therapy of Cancer

Section IX: Special Systems Pharmacology

Chapter 74: Ocular Pharmacology

Chapter 75: Dermatological Pharmacology

Chapter 76: Environmental Toxicology


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